We are studying many biological phenomena using theoretical methods, including mathematical and computational analyses. Theoretical methods are useful to decipher large amount of information, and to give an integrative understanding for the complex biological systems.
Predicting regulation of the phosphorylation cycle of KaiC clock protein using mathematical analysisPast Works
Cyanobacteria are the simplest organisms exhibiting circadian rhythms. In the bacterium, clock genes kaiA, kaiB and kaiC have been characterized as the indispensable clock regulators. KaiC plays a central role and exhibits rhythms in transcription, translation and phosphorylation status under continuous illumination conditions.
A theoretical study for gene regulatory networks and analysis of differentiated cell-statesPast Works
The highly complex behavior of organisms is based on the interactive regulation of genes, functioning together to create a gene network. The regulation of gene expression levels is dependent on the concentrations of transcriptional regulators.Typically, multiple transcription factors can bind to the regulatory region of a gene; each factor may independently affect the gene expression levels.
Mathematical models for pattern formation of leaf vascular networks.Past Works
The vascular system of plant is a network of bundles that connects within major organs. The development or differentiation of vascular system is one of the most important subjects in botany, and a lot of studies have focused the problem. In dicot systems, veins in a leaf are usually diverse in their size and they can be classified distinctively by their appearance.
Mechanism for left-right asymmetry in gene expression in early development of micePast Works
In mice early embryo left-right asymmetry of gene expression is first observed in left and right sides of node induced by the right-to-left nodal flow. From a series of experiments, we identified regulations between responsible genes, Cerl2 and Wnt, for generating left-right asymmetry.